Type 1 diabetes mellitus is a chronic medical condition that occurs when the pancreas, an organ in the abdomen, produces little or no insulin. This allows patients type 1 diabetes Daily doses of insulin are needed to meet the body’s requirements – which can be administered under the skin, either as a shot or with an insulin pump. The dosage is closely monitored and adjusted to the needs of the body over time.
While a requirement for diabetics, a JAMA Studies noted that a daily dose of human insulin, which is usually injected subcutaneously several times a day, may increase the risk of cancer in patients with type 1 diabetes. The study, using epidemiological data from the Diabetes Control and Complications Trial (DCCT) and the Diabetes Intervention and Complications (EDIC), explored the associations of risk factors with cancer incidence in patients. type 1 diabetes over a follow-up period of 28 years.
With a sample size of 1,303 patients, the study showed that the hazard ratios were significantly higher in the high-dose versus low-dose group. It analyzed 50 common risk factors such as smoking, alcoholism, medication and family history.
It noted that 93 (7 percent) of the 1,303 patients in the cohort had a cancer diagnosis, and the incidence rate was 2.8 (95 percent) per 1,000 person-years. At first diagnosis, the median age was 50 years, and the median duration of diabetes was 25 years. Among 93 patients, 57 female individuals (61 percent), 36 male individuals (39 percent), 8 (9 percent) developed cancer within 10 years, 31 (33 percent) developed cancer between 11 and 20 years, And 54 (58 percent) developed cancer between the ages of 21 and 28.
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But what is the connection?
have diabetes and cancer chronic conditions, And both of these burdens are “growing at an alarming rate in the country”, said Dr Aniket Mulay, Consultant Internal Medicine, Wockhardt Hospital Mira Road.
“Obesity may be a causative factor behind diabetes and cancer, which, in turn, leads to higher mortality and morbidity rates worldwide. According to available evidence, diabetes is caused by various changes in metabolic conditions such as insulin resistance or hyperinsulinemia. Altered is an important marker of cancer risk. In the study, people who took high doses of insulin had an increased risk of cancer diagnosis,” Dr. Muley said. However, it is too early to directly link insulin, which is a “life-saving drug” to cancer, experts said.
“While there is always a chance that is given exogenously insulin can promote growth factors that can cause proliferation of certain cells, in diabetes management, there are several therapeutic modalities, of which insulin is a lifesaving method that is almost equal to Sanjeevani herb (The medicinal herb Selaginella Bryopteris is known to cure any disease),” said Dr. Anil Bhoraskar, Senior Diabetologist, SL Raheja Hospital, Mahim, and Secretary, Diabetes Association (Scientific Section) indianexpress.com,
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Emphasizing that cancer cases are on the rise, Dr. Bhoraskar explained that “many factors” could be responsible for this. “These include nutritional deficiencies, Wind and water pollution as well as food pollution caused by the use of chemicals and fertilizers. All these factors may be responsible for inducing oxidative stress leading to free-radical formation,” he said.
Dr Tanvi Sood, Consultant- Medical Oncology, Paras Hospitals Gurugram has a lot of mixed data. “Maybe the patient has other risk factors such as pre-existing diabetes, and obesity, which lead to a higher risk of cancer formation, but with regular use insulin There is no additional risk of cancer formation, to reduce blood sugar levels and to have good control over diabetes,” she explained. indianexpress.com,
What should be done?
“It is imperative to follow a balanced lifestyle to avoid becoming stressed and anxious, and to maintain an optimal weight including healthy eating, daily exercise, staying stress free and keeping cancer at bay. manage blood sugar levelsDr Mulay said.
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